Real-time CEUS-guided biopsy revealing a littoral cell angioma of the spleen after inconclusive CT and MRI findings
Markus Herbert Lerchbaumer, Christian E. Althoff, Thomas Fischer
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin,
Humbold-Universität zu Berlin, and Berlin Institute of Health, Department of Radiology,
Correspondence: Markus H. Lerchbaumer, MD, Department of Radiology Interdisciplinary
Ultrasound Centre, Charité – Universitätsmedizin Berlin Campus Charité Mitte, Charitéplatz 1,
10117 Berlin, Germany; tel.: +49(0)30 450 657084, fax: +49(0)30 450 7557901,
The aim of this case report is to present real-time CEUS-guided biopsy for diagnosing rare benign splenic pathologies after inconclusive findings on cross-sectional imaging. We present the case of a 50-year-old male patient who received a contrast-enhanced computed tomography scan of the thorax during the evaluation for lung transplant due to lung fibrosis, with incidental finding of disseminated hypodense splenic lesions. During follow-up imaging, the patient did not tolerate a complete MRI examination, and two acquired pulse sequences did not confirm the final diagnosis. While CT-guided biopsy revealed no results, CEUS-guided target biopsy with repeated contrast injections showed a benign littoral cell angioma of the spleen. The use of real-time CEUS-guided target biopsy during lesion washout may be a useful tool to improve the accuracy of biopsy and accelerate the diagnosis in patients with parenchymal lesions after inconclusive cross-sectional imaging findings which may pose a challenge for CT-guided biopsy.